Upbeat cancer survivor Lydia and her pragmatic sister, Margaret, start a Knit to Quit group in their Blossom Street yarn store, hoping to bring in customers for weekly self-help sessions. Casey, the 12-year-old girl Lydia takes in while waiting for an infant of her own to adopt, helps out in the shop when she's not sulking in her room or causing trouble for Lydia's family. Local baker Alix wants a baby as much as Lydia does, but she and her husband agree she needs to quit smoking first. Then there's super-stressed chocolate magnate, Hutch, who takes the knitting class after his doctor suggests it. Hutch hits it off with Phoebe, who is trying to quit obsessing about a broken engagement. Rounding out the crowd, bookstore owner Ann Marie must deal with her adopted daughter Ellen's biological father, a recovering addict, re-entering their lives.