As the CDC's Dr. Ephraim Goodweather makes one last attempt to stop the swiftly moving vampire plague, he sends those dearest to him (his son and his partner) away from the city--a decision the doctor will soon regret. Meanwhile, a ragtag gang of street fighters joins forces with an elderly pawnbroker to secure an ancient tome that may reveal the secret to stopping the Master and his legion of vampires. Prepare for a showdown that will forever alter...